Holy crap, will it be a big [music]
deal? Bye-bye steroids for pretty much
everybody. The first myostatin inhibitor
drug, it can unleash pro bodybuilder
level muscle growth in all skeletal
muscles in your body without training.
>> But there are two massive caveats
[music] behind this.
>> You have to go to the hospital, you
can't just get it on the gray market. It
costs like a trillion dollars a year.
So, does that mean that myostatin
inhibitors are a dead end cuz all of
them have to be like that?
Guys, the FDA just approved for general
prescription to the public
the first myostatin inhibitor drug and
you would think this would make us
radically excited.
>> But there are two massive massive
caveats behind this.
>> And we need you guys not to fall for the
hype.
First,
what are myostatin inhibitor drugs?
Check this out.
In all of your skeletal muscles, growth
wants to go go go by default.
>> [sighs]
>> Skeletal muscle cells just want to get
more jacked. Normally, they don't have
to be coaxed to do it.
>> [gasps]
>> Myostatin is a protein [clears throat]
that reduces muscle growth to save your
metabolism for other important stuff
because we more or less evolved in times
of intermittent starvation. And if you
uncork muscle growth to just go all the
time, you're going to end up jacked and
lean and probably dead because your
liver, kidneys, heart, and brain did not
get enough food.
Myostatin inhibitors
take this blocking action of myostatin
and they reduce the production or
expression of it.
Thus, they uncork muscle growth
pretty much to maximum.
Now, if that sounds promising, it's
because it is.
The promise of myostatin is that it is
crazy powerful.
Switched completely off, it can unleash
pro bodybuilder level muscle growth in
all skeletal muscles in your body
without training.
Now, what is the evidence of this? It's
not just theory. Here's a picture of a
mouse that has myostatin blocked
compared to a regular mouse.
Here's a picture of a greyhound with no
functional myostatin gene. Look at how
scared he looks, you guys, but he's
jacked. We have myostatin negative cows,
which just kind of don't look like cows
anymore, and we even have human babies
that were documented being born one out
of a billion lucky bastards with no
functioning myostatin, and even in
babyhood, they have jacked legs. If we
have drugs that can potentially turn
dial myostatin up and down, they can
turn dial muscle growth up and down, and
by that, I mean up, of course.
>> [gasps]
>> And they can do so with almost no side
effects since it's only your skeletal
muscle that's growing.
And as a matter of fact, the research
trials on the myostatin inhibitors we
have in testing so far show health
improvements rather than detriments.
This kind of means almost anyone,
hypothetically, could have basically
good genetics for overall muscle growth
even if they don't have good genetics.
This can mean that we can have a radical
reduction in sarcopenia, age-related
muscle loss, for old folks, which is
huge because it's going to boost their
metabolisms massively, boost their
health massively, reduce inflammation
like crazy, radically improve their
strength and mobility, and make people
way more independent after bouts of
disease, and of course, the worst
disease of all, aging. Now, of course,
not the best benefit of myostatin
blockers, but the one that interests us
like crazy,
is that if you can have true myostatin
blockers that can turn down muscle, you
can turn down muscle growth up to
prevent basically all muscle loss on a
fat loss diet. Especially if paired with
modern weight loss drugs like
tirzepatide, this is an enormous,
enormous thing. If you're doing a
maintenance phase or a bulking phase,
myostatin inhibitors, myostatin
blockers,
can radically multiply the effectiveness
of your weight training routine,
provided you're taking in enough
protein, which is a lot cuz these things
grow muscle fast, and getting enough
calories. The really cool thing
hypothetically about this is that you
specialize massively on the muscles you
want to bring up. You basically do one
set per week on muscles you don't care
much about. All the muscles grow anyway,
but the specialized muscles grow way,
way faster, and thus you turn your
physique into almost exactly what you
would want to see muscle by muscle. This
would be next-level sculpting.
All right. So, the drug that was just
released to the public, with
prescription of course, is called an
easy-to-pronounce
apitegromab.
It's a monoclonal antibody,
which inhibits myostatin,
and radically elevates muscle growth.
This new drug was made by Scholar Rock,
the company, which is a sweet name for a
company that has tons of other awesome
drugs in the pipeline, and it's now
FDA-approved. Now, what cool shit did it
do in trials?
It preserved, with a very low dose,
4 lb more muscle from being lost
when folks were put on a lot of really
powerful weight loss drugs over the
course of 24 weeks than the alternative.
The tirzepatide alone group lost about
7.6 lb of lean mass.
Now, tirzepatide combined with
bimagrumab lost only 3.4 lb of muscle as
a group over 24 weeks of dieting.
That's a 55% reduction in otherwise lost
lean mass. And here's the trick, nobody
lifted weights, just the drug alone.
And you would think, okay, what's the
catch? But it didn't interfere with fat
loss. In fact, people on bimagrumab plus
tirzepatide lost about a pound more fat
than just tirzepatide alone. Because
turns out muscle growth costs even more
extra calories.
The lean tissue retention wasn't brought
on by making the whole body worse at
losing fat. In fact, it made it better.
This is such a huge deal. And because
these were super low doses, potentially
in a higher dose, you could lose zero
muscle.
And by the way, these folks were dieting
really crazy fast. If you dieted it
slower, took more bimagrumab, you could
hypothetically gain muscle and lose fat
at the same time. That is massive. And
in people with severe muscle disease,
bimagrumab improved both the amount of
muscle and physical function. This is
not muscle that doesn't work. It's real
functional muscle that you put on. This
is absolutely the real deal.
And now it's approved and out.
But
there are two reasons not to get ahead
of yourselves.
I have to tell myself this cuz I want to
get ahead of myself.
And guys, this is where the rubber meets
the road. And you're going to see lots
of videos and lots of reviews about how
this is a big deal.
It's not a big deal yet, and here's why.
Reason number one why this ain't it is
the only way to get this drug currently.
Because it's a biologic. Is in-hospital
infusion.
That means you have to go to the
hospital, sit down in a chair, get an IV
drip hooked up, and sit there for a
while getting that drug infused to you
every several weeks or every several
months. Now, it works really well for
weeks and months after that, but you
have to come back to the hospital to
keep getting the treatment. Now, look. I
can buy gray market peptides like
anybody else, but I don't exactly know
how to fake a script to go get an
in-hospital infusion. Scott, can you
imagine that? They're like, "So, looks
like you have spinal muscular
dystrophy." They're like, "Uh-huh." They
look at your spinal erectors and they're
like, "Okay."
And your doctor said you need 10 times
the approved dose of apitagramab every
two weeks instead of two months. You're
like,
"My back. It's hard for me to to talk
must my back hurts." They're like, "Sir,
don't you worry about a thing." That
That's the thing, guys. It's not a
tenable thing. You have to go to the
hospital. You can't just get it on the
gray market. You can't even get it at a
pharmacy. You can't get it falling off
the back of a truck cuz your friend
decided he didn't have spinal muscular
dystrophy anymore. You're just probably
not going to get any of this drug. Now,
if you had connections and your own
hospital bed at home with a
infusion device, I don't know. You would
get screwed by reason number two. This
drug for now, for the bodybuilding
community and fitness community is only
hype and not practical. Here's reason
number two. It costs like a trillion
dollars a year. I'm kidding, but at its
current price, it's estimated to cost
something like $350,000
a year
to administrate.
This isn't therapeutic doses, by the
way, not IFBB pro doses.
Holy crap. I don't know about you guys,
I'm pretty breaded up. I ain't spending
350k a year on a drug that grows as much
muscles as anabolic steroids. Anabolic
steroids can give me a bad mood and save
me hundreds of thousands of dollars at
the same time. Now,
not to get too depressing cuz this price
will rapidly decline.
But,
in a year, maybe it'll cost tens of
thousands instead of hundreds. And in
two or three years, it'll cost the
normal amount for drugs that kind of
everyone can afford.
But, at no point soon will it be cheap
enough to actually use for recreation or
health-based muscle growth. That's just
not on the horizon.
Combined with the fact that you have to
get it infused in the hospital, which
means first of all, you're not going to
do that, and second of all, there's no
way to fake do that, this just is not a
drug that the fitness community might
ever be using.
So, does that mean that myostatin
inhibitors are a dead end cuz all of
them have to be like that? Not quite.
What we really want is either an at-home
injectable, like a bimagrumab. You have
it in a vial, you reconstitute it,
inject it twice a week, something like
that. Or, the golden fleece, an oral
[clears throat] small molecule, which
basically means you could put the stuff
in a pill. They are working on all of
these.
When those come out, and they haven't
yet, holy crap, will it be a big deal.
Bye-bye steroids for pretty much
everybody.
Ladies will start to get real jacked
when they feel like it and have zero
androgenic effects, no having to shave
the face or hide the deep voice or any
of that stuff.
People in the public are going to get on
it like they're on Ozempic and
tirzepatide. There's going to be a
massive boost to public health because
now people can lose weight on drugs, ton
of it, but they can't keep their muscle
on. This will help them. Now,
interestingly enough, these drugs may
hurt overall gym attendance because a
lot of people just go to the gym to have
some kind of muscle that they can be
functional.
But, these drugs, I think, are going to
massively boost hardcore gym culture.
Scott, how many people want to train to
look awesome in their physique that they
just don't have the genetics to do it,
so they just give up.
>> Lots.
>> A ton. And when everyone has good
genetics, hardcore gyms are going to
fill to the brim.
Multiple companies are working on such
drugs right now. In the next probably 3
to 5 years, they're going to be
released, competitively priced, they're
going to saturate the market. You'll
even be able to get some gray market
ones from China if you like playing the
lottery, and shit will hit the fan. But
until then, we wait very patiently. And
here at RP, we'll let you know exactly
when those drugs are in the pipeline and
ready to come out or out in the market
already, so you can go, just absolutely
riddle yourself with needle marks, have
muscles coming out of your face and your
eyes, and all will be well. Until then,
see you guys at the hospital cuz
>> [laughter]
>> you like my spinal musculature just
doesn't feel right.
>> [music]
[music]