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[@RenaissancePeriodization] Best Supplements And Drugs To Get You Shredded in 2025

· 7 min read
[@RenaissancePeriodization] Summarizer
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@RenaissancePeriodization - "Best Supplements And Drugs To Get You Shredded in 2025"

Link: https://youtu.be/6DmPXKSCPHo

Short Summary​

Number One Action Item/Takeaway:

Ease into the doses of Semaglutide (Ozempic) or Tirzepatide and don't dose higher than you need.

Executive Summary:

This video reviews several supplements and drugs for fat loss, comparing their effectiveness to the gold standard, Tirzepatide. While some supplements like Berberine, caffeine, and capsaicin have minimal impact, drugs like Clenbuterol and Semaglutide (Ozempic) are significantly more effective. However, the video emphasizes the importance of a proper diet, exercise, and lifestyle habits for optimal results, especially when using powerful drugs like Semaglutide or Tirzepatide, while also cautioning against excessive dosing and potential side effects.

Key Quotes​

Okay, here are five quotes from the transcript that I found particularly insightful or noteworthy:

  1. "So, the big thing is here, ease into the doses and don't dose higher than you need. If you're like at 1 milligram and you're just coasting, you're like, "Oh my god, I don't feel hungry. I'm rocking my diet. I'm losing two pounds a week." And anyone, and I'm going to say something controversial here, including your doctor says, "You need to go up to 1.5." Don't." (This highlights the importance of individual response and avoiding unnecessary escalation of medication dosage.)

  2. "Bourberine will get you roughly the fat loss of 13% of the effect of 5 milligrams of trespathide taken uh for you know 12 weeks same 12 weeks. So if you take bourberine at about a gram and a half per day spread over three doses for 12 weeks. If you take trappatide at 5 milligrams per week, notice the per week part and uh you take that for 12 weeks, the bourberine is going to get you 13% of the fat loss on average as an expected value, which is like chi whiz." (Quantifying the relative effectiveness of supplements versus pharmaceuticals provides a clear and direct comparison.)

  3. "Compared to 5 milligrams of tzepide for an equal duration, a robust dose of clenbuterol can lead to something like 40% of the weight loss that trespide can and of the fat loss. Boy oh boy does that beat 13 9 and 3% from earlier. And guys, this right here, this is why people take drugs in in the fitness world. Say why, you know, why do people take clenbuterol? Cuz it works, man." (This is a blunt and honest assessment of why people choose to use performance-enhancing drugs, despite potential risks, and the efficacy of supplements in comparison.)

  4. "If you continue to take in high calorie bololises of food, Scott, how many Taco Bell burritos do you think you can eat in one sitting if you have like five minutes? You on osmpic on some meglletide are going to put something in your gut that takes like 18 hours to get through your gut... You're going to have a bad time. The way seaggleide works the best is if you take every single recommendation I gave earlier about how to structure your diet, very healthy foods, no crazy late night eating, very normal amounts of calories spread evenly, you're going to have an amazing time." (This emphasizes that even with medication, lifestyle choices are critical for successful outcomes and avoiding negative side effects.)

  5. "After a year and a half of using trespatide and basically doing nothing else, the average person who weighed about 200ish 220 pounds when they started lost about 35 pounds of body weight... All of the same precautions you take with Dreset. Don't eat late at night. Make your food nice and healthy. Control your calories. Get plenty of activity. Resistance. Train consistently... You can lose 20, 30, 40 pounds of fat and zero muscle." (The fact that you need both medication and lifestyle changes to reap the benefits is something that is not well known. It also addresses the idea of how to potentially gain muscle through this.)

Detailed Summary​

Here's a detailed summary of the YouTube video transcript, focusing on the key topics, arguments, and information discussed:

  • Introduction:

    • The video discusses supplements and drugs that can aid in fat loss ("shredding").
    • It excludes substances that are too hardcore, have significant side effects, or are difficult to obtain (e.g., Growth Hormone, DNP).
    • The gold standard for fat loss is considered to be tirzepatide, a pharmaceutical drug, rated at 100% effectiveness.

  • Supplements:

    • Berberine:
      • Mechanism: EMPK activation and altering glucose levels to rely more on fat.
      • Dosage: 500mg with each main meal (3x/day) for at least 12 weeks.
      • Effectiveness: 13% of the fat loss achieved with 5mg of tirzepatide for 12 weeks.
      • Caveats: May cause GI disturbance, interact with CYP3A4 medications, potentially lower vitamin B status, avoid during pregnancy.
      • Overall: Technically effective but with a tiny effect size and inconvenient dosing.
    • Green Tea Extract and Caffeine:
      • Mechanism: Caffeine increases sympathetic nervous system tone (fight or flight), green tea catechins slow caffeine breakdown.
      • Dosage: 300mg green tea extract and 200mg caffeine fasted in the morning or pre-workout.
      • Duration: 8-12 week blocks.
      • Effectiveness: 9% of the fat loss achieved with 5mg of tirzepatide.
      • Benefits: Improves workout energy, may spare muscle tissue.
      • Caveats: May cause liver stress at high doses (>700mg/day), interferes with sleep (avoid after 2 PM), consider blood work monitoring.
      • Overall: Theoretically effective but the effect may be unnoticeable.
    • Capsaicin:
      • Mechanism: Activates TRPV1 receptor, increasing sympathetic tone, thermic effect of food, and appetite suppression.
      • Dosage: 2mg active capsaicinoids per meal, just before each main meal, for 4-12 weeks.
      • Effectiveness: 3% of the fat loss achieved with 5mg of tirzepatide.
      • Caveats: May cause heartburn/lava gut if not used to spicy foods.
      • Overall: Tiny effect size and inconvenient dosing makes it not worthwhile.

  • Prerequisites for Effective Fat Loss (Regardless of Supplements/Drugs):

    • High Protein Diet: ~1 gram per pound of body weight.
    • Meal Frequency: 4-6 meals per day with evenly distributed protein.
    • Mostly Healthy Foods: Filling and provide micronutrients for proper body function.
    • Caloric Deficit: Cut 400-800 calories from maintenance intake.
    • Daily Steps: 10,000-12,000 steps per day.
    • Resistance Training: 2-6 times per week to maintain muscle mass.

  • Drugs:

    • Clenbuterol:
      • Mechanism: Beta-2 adrenergic agonist, increases resting metabolic rate and shifts metabolism towards fat oxidation.
      • Dosage: Start at 40mcg/day in the morning, titrate up to 100-120mcg/day as needed.
      • Effectiveness: 40% of the fat loss achieved with 5mg of tirzepatide.
      • Caveats: Not FDA approved for humans, not WADA approved, cardiovascular side effects (tachycardia, arrhythmias), hand tremors, potential cardiac hypertrophy, hypokalemia, requires cycling.
      • Overall: Powerful but carries significant risks and side effects.
    • Semaglutide (Ozempic):
      • Mechanism: GLP-1 receptor agonist, slows gastric emptying, reduces appetite, improves insulin response.
      • Dosage: Subcutaneous injection once a week, start at 0.25mg and titrate up slowly as needed (max 2.5mg, but don't automatically go to top dose). The goal is to eat a normal fat loss diet and feel normally hungry.
      • Effectiveness: 84% of the fat loss achieved with tirzepatide.
      • Benefits: Longevity boosting effects, improves insulin response.
      • Caveats: Nausea, rare pancreatitis or gallstones (mostly when eating high-fat junk food diets).
      • Recommendations: Avoid high-calorie boluses of food, eat healthy foods, avoid late-night eating, ease into doses, and drink workout shakes slowly.
      • Overall: Very effective and potentially beneficial for long-term health, but requires careful administration to minimize side effects.
    • Tirzepatide:
      • Mechanism: GLP-1 and GIP agonist (dual agonist), suppresses appetite even better than semaglutide with fewer side effects and hits cravings.
      • Dosage: Subcutaneous injection, start at 2.5mg and titrate up (max 15mg).
      • Benefits: Better for heart tissue, lowers cholesterol and blood pressure, reduces total body and brain inflammation, pushes back the onset of degenerative brain diseases.
      • Precautions: same as Semaglutide, but more forgiving with healthy eating
      • Overall: "A f***ing miracle drug", superior to semaglutide.

  • Synergy:

    • The best results are achieved when combining the healthy habits of diet, sleep, training, and consistency with tirzepatide.

  • Concluding remarks:

    • Tirzepatide can transform your look and health and give you the confidence to ask Stacy out.